Your patients may benefit from receiving educational materials to support them during treatment with VELCADE® (bortezomib)

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Patient Resource Kit order by email

For more patient resources please see the Financial and Personal Support sections.

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Getting Started with VELCADE Patient Resource Kit

Getting Started with
VELCADE Patient Resource Kit


The Patient Resource Kit contains:

  • Treatment Brochure for People with Multiple Myeloma
  • Lab Tests Booklet and Tracker
  • Discussion Guides for Your Healthcare Team
  • Glossary Card for Multiple Myeloma
  • Other resources
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Please read the following concerning Takeda's use of your personally identifiable information:

Takeda and its partner agencies respect your privacy and are committed to the protection of your personal information. We recognize your need for appropriate protection and management of the personally identifiable information you share with us. If you choose to provide personally identifiable information, we will use it only for the purpose for which you submitted it to us. We may collect and analyze this information to better understand the effectiveness of our service activities. However, we do not collect or maintain personally identifiable information for resale purposes, or share your information with any other unaffiliated company or organization. Any and all uses of personally identifiable information comply with all applicable United States laws. By submitting personally identifiable information, you waive any rights you may have under any law of any other country or region.

Takeda may, at any time, revise this Privacy Statement. Data will be handled in accordance with the policy in effect at the time the data is collected.

By submitting this form, you acknowledge that you understand the above statement and consent to Takeda's use of the personally identifiable information you share with Takeda.

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Financial Support for Your Patients

Visit www.VELCADE.com to access more financial support tools for your patients.

A diagnosis of cancer, or a relapse of disease, can create many questions and concerns for patients. They may be worried about understanding their diagnosis, following their treatment plan, or paying for treatment.

Help for patients dealing with multiple myeloma comes in many forms, including programs and services that provide legal and financial support.

The VELCADE Reimbursement Assistance Program (VRAP) helps patients:

  • Understand insurance and coverage*
  • Identify alternative and supplemental insurance coverage options
  • Access information on co-payment foundation support, including financial assistance with:
    • Prescription drug co-insurance, co-payments, and deductibles
    • Health insurance premiums
    • Other select out-of-pocket healthcare costs

*VRAP does not file claims or appeal claims for callers, and it cannot guarantee that you will be successful in obtaining reimbursement.

Click below to download and share financial support tools, including reimbursement support and co-pay assistance for VELCADE® (bortezomib).

Understanding Multiple Myeloma Treatment Brochure

A guide to understanding multiple myeloma, treatment, financial assistance, and additional resources for patients.

VRAP Enrollment Form

Help patients enroll to get answers about coverage and assistance in paying for treatment.

Co-pay Foundation

Connect patients with organizations that can help pay for drug co-insurance, co-pays, deductibles, insurance premiums, and more.

Transportation Assistance Sheet

A list of organizations that may be able to provide your patients with assistance getting to and from their appointments.

Indications and Important Safety Information for VELCADE® (bortezomib)


VELCADE (bortezomib) is indicated for the treatment of patients with multiple myeloma.


VELCADE is contraindicated in patients with hypersensitivity (not including local reactions) to bortezomib, boron, or mannitol, including anaphylactic reactions. VELCADE is contraindicated for intrathecal administration. Fatal events have occurred with intrathecal administration of VELCADE.


VELCADE (bortezomib) is for subcutaneous or IV administration only. Because each route of administration has a different reconstituted concentration, caution should be used when calculating the volume to be administered.

  • Peripheral neuropathy, including severe cases, may occur. Patients should be monitored for symptoms and managed with dose modification or discontinuation. Patients with preexisting symptoms may experience worsening peripheral neuropathy (including ≥Grade 3). Starting with VELCADE subcutaneously may be considered for patients who either have preexisting or are at high risk for peripheral neuropathy.
  • Hypotension: Caution should be used when treating patients receiving antihypertensives, those with a history of syncope, and those who are dehydrated.
  • Cardiac toxicity, including acute development or exacerbation of congestive heart failure and new onset of decreased left ventricular ejection fraction, has occurred. Isolated cases of QT-interval prolongation have been reported. Patients with risk factors for, or existing, heart disease should be closely monitored.
  • Pulmonary toxicity: Acute respiratory distress syndrome (ARDS) and acute diffuse infiltrative pulmonary disease of unknown etiology have occurred (sometimes fatal). Pulmonary hypertension, in the absence of left heart failure or significant pulmonary disease, has been reported. In the event of new or worsening cardiopulmonary symptoms, consider interrupting VELCADE until a prompt and comprehensive diagnostic evaluation is conducted.
  • Posterior reversible encephalopathy syndrome has occurred. Consider MRI imaging for onset of visual or neurological symptoms; discontinue VELCADE if suspected.
  • Gastrointestinal toxicity, including nausea, diarrhea, constipation, and vomiting, has occurred and may require use of antiemetic and antidiarrheal medications or fluid replacement. Interrupt VELCADE (bortezomib) for severe symptoms.
  • Thrombocytopenia/Neutropenia: Manage with dose and/or schedule modifications. Complete blood counts should be monitored frequently during treatment. There have been reports of gastrointestinal and intracerebral hemorrhage. Support with transfusions and supportive care, according to published guidelines.
  • Tumor lysis syndrome: Closely monitor patients with high tumor burden and take appropriate precautions.
  • Hepatic toxicity: Monitor hepatic enzymes during treatment. Upon occurrence, interrupt therapy with VELCADE to assess reversibility.
  • Embryo-fetal risk: Women should avoid breast-feeding or becoming pregnant while on VELCADE.
  • Patients with diabetes may require close monitoring and adjustment of the antidiabetic medications.


Closely monitor patients receiving VELCADE (bortezomib) in combination with strong CYP3A4 inhibitors. Avoid concomitant use of strong CYP3A4 inducers.


  • Previously untreated multiple myeloma (MM): In the phase 3 study of VELCADE administered intravenously with melphalan and prednisone (MP) vs MP alone, the most commonly reported adverse reactions (ARs) were thrombocytopenia (48% vs 42%), neutropenia (47% vs 42%), peripheral neuropathy (46% vs 1%), nausea (39% vs 21%), diarrhea (35% vs 6%), neuralgia (34% vs <1%), anemia (32% vs 46%), and leukopenia (32% vs 28%).
  • Relapsed MM subcutaneous vs IV: In the phase 3 study of VELCADE (bortezomib) administered subcutaneously vs intravenously in relapsed MM, safety data were similar between the two treatment groups. The most commonly reported ARs in the subcutaneous vs IV treatment groups were peripheral neuropathy (37% vs 50%) and thrombocytopenia (30% vs 34%). The incidence of serious ARs was similar in the subcutaneous treatment group (20%) and the IV treatment group (19%). The most commonly reported serious ARs were pneumonia and pyrexia (each 2%) in the subcutaneous treatment group and pneumonia, diarrhea, and peripheral sensory neuropathy (each 3%) in the IV treatment group.
  • Relapsed MM: In the integrated analysis of 1163 patients in phase 2 and 3 studies of VELCADE administered intravenously, the most commonly reported ARs were nausea (49%), diarrhea NOS (46%), fatigue (41%), peripheral neuropathy NEC (38%), and thrombocytopenia (32%). A total of 26% of patients experienced serious ARs. The most commonly reported serious ARs included diarrhea, vomiting, and pyrexia (each 3%); nausea, dehydration, and thrombocytopenia (each 2%); and pneumonia, dyspnea, peripheral neuropathies NEC, and herpes zoster (each 1%).

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